FGF signals specifically regulate the structure of hair shaft medulla via IGF-binding protein 5.

نویسنده

  • Thomas Schlake
چکیده

Reciprocal interactions between the dermal papilla and the hair matrix control proliferation and differentiation in the mature hair follicle. Analysis of expression suggests an important role for FGF7 and FGF10, as well as their cognate receptor FGFR2-IIIb, in these processes. Transgenic mice that express a soluble dominant-negative version of this receptor in differentiating hair keratinocytes were generated to interfere with endogenous FGF signalling. Transgenic mice develop abnormally thin but otherwise normal hairs, characterised by single columns of medulla cells in all hair types. All structural defects and the accompanying changes of global gene expression patterns are restricted to the hair medulla. Forced transgenic expression of IGF-binding protein 5, whose expression level is elevated upon suppression of FGFR2-IIIb-mediated signalling largely phenocopies the defect of dnFgfr2-IIIb-expressing hairs. Thus, the results identify Igfbp5-mediated FGFR2-IIIb signals as a key regulator of the genetic program that controls the structure of the hair shaft medulla.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Krox20, a novel candidate for the regulatory hierarchy that controls hair shaft bending

Murine hair follicle morphogenesis gives rise to four distinct pelage follicle types that produce hair shafts differing in length, the number of medulla columns, and the presence and number of bends. Recently, Igfbp5 was identified as the first molecular marker that distinguishes among different hair follicle types and shown to mark zigzag hairs. Further, it was demonstrated that Igfbp5 express...

متن کامل

Segmental Igfbp5 expression is specifically associated with the bent structure of zigzag hairs

The murine hair coat consists of four different hair types that are characterised by hair length, the number of medulla columns, and the presence and number of bends. The molecular mechanisms underlying the establishment and maintenance of distinct hair follicle fates are unknown. We identify Igfbp5 as the first molecular marker that distinguishes among different hair follicle types. High-resol...

متن کامل

Hair Shaft Abnormality in Children: a Narrative Review

Background Hair is an ectodermal structure, and its formation is regulated by master genes important in embryology. Hair shaft consists of three major regions: the medulla, cortex and cuticle. Hair shaft abnormality will divide structural hair abnormalities into two broad categories - those associated with increased hair fragility and those not associated with increased hair fragility. We condu...

متن کامل

Investigation on the Levels of IGF-I Receptor and IGF-I Binding Protein I in the Brain of Insulin Resistant Rats

Abstract Introduction: There is limited knowledge available on the metabolism of glucose in the brain, an insulin insensitive organ. Insulin receptors hybridize with insulin like growth factor receptor (IGF-I) to transduce the signals in different areas of the brain. In this article we aimed at investigating whether the expression of IGF-I receptor and IGF-I binding proteins (IGFBP1) is change...

متن کامل

Hair Shafts

L. Rudnicka et al. (eds.), Atlas of Trichoscopy, DOI 10.1007/978-1-4471-4486-1_2, © Springer-Verlag London 2012 Most hairs viewed on trichoscopy are normal terminal hairs that are more than 55 m m wide and are uniform in thickness and color [ 1, 2 ] . Hair shaft thickness may be roughly estimated with a handheld dermoscope (thin, normal, thick). Many videodermoscopes include software allowing a...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Development

دوره 132 13  شماره 

صفحات  -

تاریخ انتشار 2005